U.S. Dept Commerce/NOAA/NMFS/NWFSC/Publications
TABLE 2.2.
Site of capture and age as risk factors for liver lesions in English sole,
Flatfish Toxicopathic Injury Study. Male and female English sole were included in this
analysis, and reference fish from Colvos Passage from both the Flatfish Toxicopathic and
Reproductive Injury Studies were also included. Logistic regression was used to calculate
the odds ratios/relative risks associated with fish age, and residence in Hylebos
Waterway. Significant or nearly significant relative risks and p values are shown
in bold type. RRe = estimated relative risk. GM = grand mean; overall odds of
lesion occurrence for entire dataset. 11th St. Br. = 11th Street Bridge site;
LTB = Lower Turning Basin site; UTB = Upper Turning Basin site. n = 371 individuals.
| LESION | RISK FACTOR | ODDS RATIO/RRe | P VALUE |
| Neoplasms | Age | 1.41a | 0.001 |
| (GM= 0.1592E-2) | Hylebos 11th St. Br. | ------- | 0.085 |
| Hylebos LTB | ------- | 0.134 | |
| Hylebos UTB | ------- | 0.831 | |
| Foci of cellular alteration | Age | 1.44 | 0.001 |
| (GM=0.4118E-2) | Hylebos 11th St. Br. | ------- | 0.750 |
| Hylebos LTB | ------- | 0.118 | |
| Hylebos UTB | ------- | 0.156 | |
| Specific degeneration/ | Age | ------- | 0.963 |
| necrosis | Hylebos 11th St. Br. | 17.55 | 0.010 |
| (GM=0.5181E-2) | Hylebos LTB | 21.85b | 0.005 |
| Hylebos UTB | 73.52 | 0.001 | |
| Proliferative lesions | Age | 1.13 | 0.037 |
| (GM=0.2490E-1) | Hylebos 11th St. Br. | 3.76 | 0.053 |
| Hylebos LTB | ------- | 0.418 | |
| Hylebos UTB | 3.71 | 0.004 | |
| Any toxicopathic lesionc | Age | 1.23 | 0.001 |
| (GM=0.2986E-1) | Hylebos 11th St. Br. | 2.83 | 0.008 |
| Hylebos LTB | ------- | 0.176 | |
| Hylebos UTB | 6.88 | 0.001 | |
a Odds ratios for age represent the effect of each additional year of age on the odds of disease occurrence. In other words, regardless of site of capture, an English sole in this study is 1.41 times as likely to have neoplasms with each additional year of age.
b Odds ratios for site are interpreted relative to the age-adjusted lesion occurrence data for all English sole from the reference site at Colvos Passage combined from both studies. In other words, an English sole from the Lower Turning Basin site in the Hylebos Waterway is over 21.85 times as likely to have specific degeneration/necrosis than a comparably aged English sole from the reference site.
c The "any toxicopathic lesion" category includes fish affected with neoplasms, foci of cellular alteration, specific degeneration/necrosis, or proliferative lesions.
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