U.S. Dept Commerce/NOAA/NMFS/NWFSC/Publications
TABLE 2.4.
Biliary FACs as risk factors for liver lesions in English sole, combined studies.
Logistic regression was used to calculate the odds ratios/estimated relative risks
associated with biliary FACs levels and fish age. Significant or nearly significant
relative risks and p values are shown in bold type. RRe = estimated relative risk.
GM = grand mean; overall odds of lesion occurrence for entire dataset. n = 206 individuals.
| LESION | RISK FACTOR | ODDS RATIO/RRe | P VALUE | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Neoplasms | Age | 1.60 - 1.65a | 0.001 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| (GM=0.1933 to 0.2608E-3) | FACsBaP | 1.001b | 0.009 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FACsNPH | 1.000+b | 0.023 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FACsPHN | 1.000+b | 0.011 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Foci of cellular alteration | Age | 1.47 - 1.48 | 0.001 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| (GM=0.3157 to 0.5710E-2) | FACsBaP | ------- | 0.511 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FACsNPH | ------- | 0.084 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FACsPHN | 1.000+| 0.051
|
| Specific degeneration/ | Age | ------- | 0.745
| necrosis | FACsBaP | ------- | 0.063
| (GM=0.3518E-1) | FACsNPH | ------- | 0.191 |
| FACsPHN | ------- | 0.077
|
| Proliferative lesions | Age | ------- | 0.419
| (GM=0.9574E-1) | FACsBaP | ------- | 0.617
| FACsNPH | ------- | 0.119 |
| FACsPHN | ------- | 0.054
| Any toxicopathic lesionc
| (GM=0.2522-0.4745E-1) | Age | 1.25 - 1.29 | 0.001
| FACsBaP | ------- | 0.057
| FACsNPH | 1.000+ | 0.001 |
| FACsPHN | 1.000+ | 0.001
| | |||||||||||
a Odds ratios for age represent the effect of each additional year of age on the odds of disease occurrence. In other words, regardless of site of capture, an English sole in this study is 1.60 to 1.65 times as likely to have a neoplasm with each additional year of age.
b Odds ratios for FACs represent the effect of each additional unit of value (ng (BaP, NPH, PHN)eq/mg bile protein) on odds of disease occurrence. In other words, each additional ng BaP equivalent/mg bile protein detected in bile increases the probability of being affected with a neoplasm by 1.001 times. The RRe for FACsNPH and FACsPHN are very small (< 1.0005), but the cumulative effect of increasing levels on the odds of lesion occurrence is still significant (p < 0.05) by logistic regression analysis. FACsBaP = biliary FACs measured at benzo[a]pyrene wavelengths; FACsNPH = biliary FACs measured at naphthalene wavelengths; FACsPHN = biliary FACs measured at phenanthrene wavelengths.
c The "any toxicopathic lesion" category includes fish affected with neoplasms, foci of cellular alteration, specific degeneration/necrosis, or proliferative lesions.
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