TABLE 2.6.
Hepatic DNA adducts as risk factors for liver lesions in female English sole, Reproductive Injury Study. Logistic regression analyses of hepatic lesion occurrence and hepatic DNA adducts in female English sole data from the Flatfish Reproductive Injury Study. This table shows the p values for the odd ratios/estimated relative risks associated with the DNA adduct risk factor, while simultaneously adjusting for influence of mean fish age on probability of lesion occurrence. Significant relative risks and p values are shown in bold type. FCA = foci cellular alteration. Prolif = non-neoplastic proliferative lesions. SDN = specific degenerative/necrotic lesions. Any Tox Lesion = any toxicopathic hepatic lesion. RRe = estimated relative risk. GM = grand mean; overall odds of lesion occurrence for entire dataset. n = 80 individuals.

^a Odds ratios for age represent the effect of each additional year of age on the odds of disease occurrence. In other words, regardless of site of capture, an English sole in this analysis is 1.81 times as likely to have a neoplasm with each additional year of age.

^b Odds ratios for adducts represent the effect of each additional unit of value (nanomoles adducts/mole DNA bases) on odds of disease occurrence. In other words, each additional nanomole of adducts/mole DNA bases increases the probability of being affected with a focus of cellular alteration by 1.06 times.

^c The "any toxicopathic lesion" category includes fish affected with neoplasms, foci of cellular alteration, specific degeneration/necrosis, or proliferative lesions.

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