NOAA/NMFS/NWFSC TM-36: Fish Injury in the Hylebos Waterway

U.S. Dept Commerce/NOAA/NMFS/NWFSC/Publications

NOAA Tech Memo NMFS NWFSC-36: Fish Injury in the Hylebos Waterway (cont)

TABLE 2.7.
Hepatic DNA adducts as risk factors for liver lesions in English sole, combined studies. Logistic regression was used to calculated the p values for the odd ratios/estimated relative risks associated with the DNA adduct risk factor, while simultaneously adjusting for influence of mean fish age on probability of lesion occurrence. Significant relative risks and p values are shown in bold type. Male and female English sole from the toxicopathic study, and female English sole from the reproductive study were used in these calculations. FCA = foci cellular alteration. Prolif = non-neoplastic proliferative lesions. SDN = specific degenerative/necrotic lesions. Any Tox Lesion = any toxicopathic hepatic lesion. RR_e = estimated relative risk. GM = grand mean; overall odds of lesion occurrence for entire dataset. n = 8 composite analyses.


LESION	RISK FACTOR	ODDS RATIO/RR_e	P VALUE

Neoplasms	Mean age	-------	0.661
(GM= 0.2395E-1)	Mean DNA adducts	-------	0.460

Foci of cellular alteration	Mean age	-------	0.625
(GM=0.6542E-1)	Mean DNA adducts	-------	0.241

Specific degeneration/	Mean Age	-------	0.542
necrosis	Mean DNA adducts	1.024^a	0.001
(GM=0.2300E-1)

Proliferative lesions	Mean Age	2.222^b	0.020
(GM=0.1066E-2)	Mean DNA adducts	1.009	0.056

Any toxicopathic lesion^c	Mean Age	1.638	0.022
(GM=0.1150E-1)	Mean DNA Adducts	1.012	0.001

^a Odds ratios for adducts represent the effect of each additional unit of value (nanomoles adducts/mole DNA bases) on odds of disease occurrence. In other words, each additional nanomole of adducts/mole DNA bases increases the probability of being affected with specific degeneration/necrosis by 1.024 times.

^b Odds ratios for age represent the effect of each additional year of age on the odds of disease occurrence. In other words, regardless of site of capture, an English sole in this study is 2.22 times as likely to have proliferative lesion with each additional year of age.

^c The "any toxicopathic lesion" category includes fish affected with neoplasms, foci of cellular alteration, specific degeneration/necrosis, or proliferative lesions.

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