Dr. Mark Strom
Program Manager
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Aeromonas salmonicida
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R. salmoninarum Genome
Project
Vibrio vulnificus
Diagnostics development,
identification tools
Applied Studies
BKD vaccines
and chemotherapeutics
Disease Diagnostics
and Pathology
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Current Research - Vibrio vulnificus
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Analyzing oysters for presence of
experimentally introduced vibrio vulnificus
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Our laboratory is carrying out research on the mechanisms of virulence
of Vibrio vulnificus, a bacterium normally found in temperate
estuarine waters, and as a colonizer of molluscan shellfish such as
oysters. This organism does not normally cause serious disease in humans
(usually a self-limiting gastroenteritis). However, in predisposed
individuals, especially those who suffer from underlying liver disease,
hemachromatosis, or other chronic or immunosuppressive disease, this
organism can cause serious, life threatening septicemia after ingestion
of contaminated oysters. It is also capable of causing serious wound
infections by introduction of the organism through a break in the skin.
Vibrio vulnificus pili
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Our work on V. vulnificus has focused on adherence mechanisms and
secretion of virulence factors, such as degradative toxins. With respect
to specific adhesins, such as pili (see arrows in image at
right, click on image for larger view), we are interested in not only how these factors influence the
course of mammalian colonization and infections, but also how they
influence the organism's ability to colonize and persist in
shellfish.
More information:
Project lead(s): Paranjpye, Strom
Published papers
Nilsson, W. B., R. N. Paranjpye, A. DePaola, and M. S. Strom. 2003. Sequence polymorphisms in the 16S
rRNA gene of Vibrio vulnificus is a possible indicator of strain virulence. J.
Clin. Microbiol. 41:442-446. [Abstract:
JCM]
Strom, M. S. and R. N. Paranjpye. 2001. Characterization of components of type IV pili and type II
extracellular secretion in Vibrio vulnificus and determination of their role in virulence.
Bull. Natl. Res. Int. Aquacult. Suppl. 5:35-44.
Strom, M. S. and R. N. Paranjpye. 2000. Epidemiology and pathogenesis of Vibrio vulnificus.
Microbes and Infection: 177-188. [
Abstract]
Paranjpye, R. N., J. C. Lara, J. C. Pepe, C. M. Pepe and M. S. Strom. 1998. The type IV leader
peptidase/N-methyltransferase of Vibrio vulnificus controls factors required for
adherence to HEp-2 cells and virulence in iron-overloaded mice.
Infection and Immunity 66:5659-5668.
Recent Meeting Presentations
Paranjpye, R. N. and M. S. Strom. 2001. A Vibrio vulnificus type IV pilus is required for
virulence in iron dextran-treated mice. Cold Spring Harbor Laboratory Symposium "Microbial
Pathogenesis and Host Defense", Cold Spring Harbor Laboratory, New York, September 12-16, 2001.
Paranjpye, R. N. and M. S. Strom. 2001. Characterization of a Type IV
Pilus of Vibrio vulnificus Required for Virulence. Abstract, The 101st General Meeting
of the American Society for Microbiology, May 20-24, 2001.
Strom, M. S. and R. N. Paranjpye. 2000. Characterization of Components of Type IV Pili and Type II Extracellular Secretion in Vibrio vulnificus and Determination of Their Role in Virulence. Pathogenic Organisms and Disease
Prevention Symposium, United States/Japan Natural Resources (UJNR) Aquaculture
Panel, Ise, Japan, November 7-9, 2000.
Paranjpye, R. N. and M. S. Strom. 1999. Characterization of a type IV pilus in
Vibrio vulnificus. Cold Spring Harbor Laboratory Symposium "Microbial Pathogenesis and Host Defense", Cold Spring Harbor Laboratory,
New York, September 22-26, 1999.
Strom, M. S., R. N. Paranjpye, C. M. Pepe, and J. C. Lara. The type IV leader
peptidase/N-methyltransferase of Vibrio vulnificus controls factors required for type II
protein secretion, adherence to epithelial cells, and virulence in iron-overloaded mice.
Given at the "Fimbriae and Pili" Symposium, Australian Society for Microbiology Annual
Meeting, Hobart, TAS, Australia, September 27-October 3, 1998 (invited paper).
Strom, M. S., C. M. Pepe, R. N. Paranjpye, J. C. Pepe, and J. B. Bell. 1997. Characterization of
type IV peptidase mutants of Aeromonas hydrophila and Vibrio vulnificus may lead
to the identification of novel virulence determinants. Abstract, Cold Spring Harbor
Laboratory Symposium "Microbial Pathogenesis and Host Defense", Cold Spring Harbor Laboratory,
New York, September 10-14, 1997, p. 102.
Paranjpye, R. and M. S. Strom. 1997. Cloning and characterization of a
type IV pilin homologue from Vibrio vulnificus. Abstract, American
Association for the Advancement of Science Annual Meeting p. A-94.
Strom, M. S., and J. Cano Lara. 1995. Isolation of genes involved in type
IV pilus biogenesis from Vibrio vulnificus. Abstract, The 95th General
Meeting of the American Society for Microbiology, p. 256.
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