Northwest Fisheries Science Center

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Document Type: Journal Article
Center: NWFSC
Document ID: 4491
Title: Efficacy of cellular vaccines and genetic adjuvants against bacterial kidney disease in chinook salmon (Oncorhynchus tshawytscha)
Author: L. D. Rhodes, C. K. Rathbone, Steve C. Corbett, Lee W. Harrell, M. S. Strom
Publication Year: 2004
Journal: Fish and Shellfish Immunology
Volume: 16
Issue: 4
Pages: 461-474
DOI: 10.1016/j.fsi.2003.08.004
Keywords: bacterial kidney disease

 DNA adjuvants and whole bacterial cell vaccines against bacterial kidney disease (BKD) were tested in juvenile chinook salmon. Whole cell vaccines of either a nonpathogenic Arthrobacter spp. or an attenuated Renibacterium salmoninarum strain provided limited prophylactic protection against acute intraperitoneal challenge with virulent R. salmoninarum, and the addition of either synthetic oligodeoxynucleotides or purified R. salmoninarum genomic DNA as adjuvants did not increase protection. However, a combination of both whole cell vaccines significantly increased survival among fish naturally infected with R. salmoninarum, and the surviving fish treated with the combination vaccine exhibited reduced levels of bacterial antigens in the kidney. This is the first demonstration of a potential therapeutic effect of a whole cell vaccine against BKD.

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Theme: Recovery, Rebuilding and Sustainability of Marine and Anadromous Species
Foci: Maximize effectiveness and minimize impacts of artificial propagation in recovery, rebuilding and stock sustainability