Northwest Fisheries Science Center

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Document Type: Journal Article
Center: NWFSC
Document ID: 5885
Title: Field and laboratory studies of the etiology of liver neoplasms in marine fish from Puget Sound
Author: Donald C. Malins, Bruce B. McCain, Mark S. Myers, Donald W. Brown, Margaret M. Krahn, W. T. Roubal, Michael H. Schiewe, John T. Landahl, Sin Lam Chan
Publication Year: 1987
Journal: Environmental Health Perspectives
Volume: 71
Issue: April
Pages: 5-16
Abstract:

A series of field studies was conducted between 1979 and 1985 in Puget Sound, Washington State, to investigate etiological relationships between prevalences of hepatic neoplasms in bottom–dwelling marine fish species, with emphasis on English sole (Parophrys vetulus), and concentrations of toxic chemicals in sediments and affected fish.  Statistically significant (p ≤ 0.05) correlations have been found between the prevalences of hepatic neoplasms in English sole and the following parameters:  sediment concentrations of aromatic hydrocarbons, and concentrations of the metabolites of aromatic compounds in the bile of affected sole.  A significant difference (p < 0.001) was also found between the relative concentrations of aromatic free radicals in the liver microsomes of English sole with liver lesions compared to sole without liver lesions.  Laboratory studies designed to evaluate the etiology of the liver neoplasms in English sole have also yielded evidence that is consistent with the view that high molecular weight aromatic hydrocarbons, e.g., benzo[a]pyrene (BaP), are hepatocarcinogens in English sole.  The current status of a series of long–term (up to 18 months) exposures of English sole and rainbow trout (Salmo gairdneri) to selected fractions of Puget Sound sediment extracts, enriched with aromatic hydrocarbons and nitrogen–containing aromatic compounds, and to individual carcinogens (e.g., BaP) is discussed.  

URL1: The next link will exit from NWFSC web site http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474350/
Notes: No doi but full text available free from PubMed Central (July 2014)