Northwest Fisheries Science Center

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Document Type: Journal Article
Center: NWFSC
Document ID: 6984
Title: In vitro inhibition of rat brain ATPase, pNPPase, and ATP–32Pi exchange by chlorinated–diphenyl ethanes and cyclodiene insecticides
Author: Leroy C. Folmar
Publication Year: 1978
Journal: Bulletin of Environmental Contamination and Toxicology
Volume: 19
Issue: 1
Pages: 481-488

Recent reports have demonstrated that organochlorine insecticides inhibit vertebrate and invertebrate ATPase both in vitro and in vivo.  However, the results of these studies are not in complete agreement as to the primary site of inhibitory action.  Na+–K+ ATPase activity from several sources was reported to be highlysensitive to p, p' DDT and its analogs, and was considered to be the primary site of action for these chemicals& 

Because of the conflicting reports on the action of chlorinated diphenyl insecticides on Na+–K+ ATPase and the apparent differences in physiological response to diphenyl and cyclodiene compounds on different types of tissues, this study was initiated to determine the effects of both groups of insecticides on a single species. Experiments were conducted to determine the effects of representative chlorinated diphenyl and cyclodiene compounds on rat brain Na+–K+ ATPase, pNPPase (a model for the K+ mediated portion of the overall Na+–K+ ATPase reaction, and ATP–32Pi exchange (a measure of oxidative phosphorylation comparable with oligomycin sensitive Mg++ATPase.

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