|Document Type:||Journal Article|
|Title:||Specificity of protection induced in coho salmon (Oncorhynchus kisutch) by heat–treated components of two pathogenic vibrios|
|Author:||Michael H. Schiewe, Harold O. Hodgins|
|Journal:||Journal of the Fisheries Research Board of Canada|
A series of in vivo comparisons between two marine vibrios pathogenic to pen–reared salmon demonstrated that each organism possessed protection–inducing, heat–stable components that were unique and others that were cross–protective. In all instances, however, immunization with the components of the homologous bacterium produced the highest degree of protection in juvenile coho salmon (Oncorhynchus kisutch) against subsequent live–bacteria challenge. Antigenic competition was not detected when fish were immunized with both bacteria, indicating that a bivalent vaccine would be effective against infection by either vibrio.