Northwest Fisheries Science Center

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Document Type: Journal Article
Center: OHHI
Document ID: 819
Title: Biomarker response and disease susceptibility in juvenile rainbow trout Oncorhynchus mykiss fed a high molecular weight polycyclic aromatic hydrocarbon (PAH) mixture
Author: C. F. Bravo, L. R. Curtis, Mark S. Myers, J. P. Meador, Lyndal L. Johnson, J. Buzitis, T. K. Collier, J. D. Morrow, C. A. Laetz, F. Loge, M. R. Arkoosh
Publication Year: 2011
Journal: Environmental Toxicology and Chemistry
Volume: 30
Issue: 3
Pages: 704-714
DOI: 10.1002/etc.439
Keywords: rainbow trout, PAHs, oxidative stress, AHR, disease susceptibility, Aeromonas salmonicida, toxicity

 Juvenile rainbow trout were fed a diet containing an environmentally relevant mixture of 10 high molecular weight polycyclic aromatic hydrocarbons (PAHs) at a dose of 0.66 or 7.82 µg PAH · g fish−1 · d−1. At 3, 7, 14, and 28 d, biomarkers of aryl hydrocarbon receptor activation (AHR), hepatic microsomal ethoxyresorufin-O-deethylase (EROD) activity, and cytochrome P4501A (CYP1A)-associated staining increased 14- to 26-fold and 6- to 14-fold, respectively, in fish fed 7.82 µg PAH · g fish −1 · d

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The Northwest Fisheries Science Center (NWFSC) supports the conservation and management of living marine resources and their habitats in the Northeast Pacific Ocean.

Our research assists resource managers in making sound decisions that build sustainable fisheries, recover endangered and threatened species, sustain healthy ecosystems, and reduce risks to human health.