Northwest Fisheries Science Center

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Document Type: Journal Article
Center: NWFSC
Document ID: 8199
Title: Phenylhydrazine-induced anemia in chinook salmon
Author: C. E. Smith, Lynn R. McLain, Waldo S. Zaugg
Publication Year: 1971
Journal: Toxicology and Applied Pharmacology
Volume: 20
Issue: 1
Pages: 73-81

Single injections of phenylhydrazine (12.5 μg/g body weight) produced severe hemolytic anemia in chinook salmon (Oncorhynchus tshawytscha).  Within 10 days erythrocyte counts, hemoglobin concentrations, and hematocrits were reduced to 1–5% of normal.  Microscopic examination revealed pronounced swelling and rupture of erythrocyte nuclei and degenerated erythrocytes in blood vessels of all organs studied.  Histologic changes were noted in the kidney, liver and spleen.  Blood components returned to near normal levels 95 days after injection. 

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