Northwest Fisheries Science Center

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Document Type: Journal Article
Center: NWFSC
Document ID: 8809
Title: Molecular mechanisms of crude oil developmental toxicity in fish
Author: J. P. Incardona
Publication Year: 2017
Journal: Archives of Environmental Contamination and Toxicology
Keywords: oil spills,polycyclic aromatic hydrocarbons,embryology,heart development,pollutants,cardiovascular
Abstract:

With major oil spills in Korea, the United States, and China in the last decade, there
has been a dramatic increase in the number of studies characterizing the
developmental toxicity of crude oil and its associated polycyclic aromatic compounds
(PACs). The use of model fish species with associated tools for genetic manipulation,
combined with high throughput genomics techniques in non-model fish species have
led to significant advances in understanding the cellular and molecular bases of
functional and morphological defects arising from embryonic exposure to crude oil.
Following from the identification of the developing heart as the primary target of crude
oil developmental toxicity, studies on individual PACs have revealed a diversity of
cardiotoxic mechanisms. For some PACs that are strong agonists of the aryl
hydrocarbon receptor (AHR), defects in heart development arise in an AHR-dependent
manner as has been shown for potent organochlorine agonists such as dioxins.
However, crude oil contains a much larger fraction of compounds that have been found
to directly interfere with cardiomyocyte physiology in an AHR-independent manner. By
comparing the cellular and molecular responses to AHR-independent and AHRdependent
toxicity, this review focuses on new insights into heart-specific pathways
underlying both acute and secondary adverse outcomes to crude oil exposure during
fish development.

Theme: Habitats to Support Sustainable Fisheries and Recovered Populations
Foci: Assess the impacts of toxic chemicals and other pollutants across biological scales, and identify pollution reduction strategies that improve habitat quality.
Characterize the interaction of human use and habitat distribution, quantity and quality.