Northwest Fisheries Science Center

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Document Type: Journal Article
Center: NWFSC
Document ID: 8900
Title: Population-Relevant Endpoints in the Evaluation of Endocrine-active Substances (EAS) for Ecotoxicological Hazard and Risk Assessment
Author: M. S. Marty, A. Blankenship, J. Chambers, L. Constantine, W. Kloas, A. Kumar, L. Lagadic, J. P. Meador, D. Pickford, T. Schwarz, T. Verslycke
Publication Year: 2017
Journal: Integrated Environmental Assessment and Management
Volume: 13
Issue: 2
Pages: 317-330
DOI: 10.1002/ieam.1887
Keywords: endocrine disruption,populations,hazard assessment,risk assessment

For ecotoxicological risk assessment, endocrine disrupters require the establishment of an endocrine mode of action (MoA) with a plausible linkage to a population-relevant adverse effect.  Current ecotoxicity test methods mostly incorporate apical endpoints although some also include mechanistic endpoints, subcellular-through-organ-level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population-level effects is often unclear. The case studies of endocrine-active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated for the SETAC Pellston Workshop™:  Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Chemicals were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine disruptor frameworks such as the OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters.  A wide variety of potentially-relevant endpoints were identified for mollusks, fish, amphibians, birds and mammals, although the strength of the relationship between test endpoints and population-level effects was often uncertain.  Furthermore, testing alone is insufficient for assessing potential adaptation and recovery processes in exposed populations.  For this purpose, models that link effects observed in laboratory tests to the dynamics of wildlife populations appear to be necessary and their development requires reliable and robust data.  As our understanding of endocrine perturbations and key event relationships improves, adverse population level effects will be more easily and accurately predicted.

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Theme: Ecosystem approach to improve management of marine resources
Foci: Describe the interaction between human activities, particularly harvest of marine resources, and ecosystem function.
Provide scientific support for the implementation of ecosystem-based management